The B-cell-specific activator protein, PAX-5, is a nuclear transcription factor which plays a major role in B-cell differentiation and proliferation. PAX expression is increased during early B-cell development and retained throughout maturation, but is absent in plasma cells and T-cells. PAX-5 is expressed in the vast majority of B-cell malignancies. In addition, PAX-5 immunoreactivity is detected in subsets of epithelial and mesenchymal tumors, including poorly differentiated neuroendocrine carcinoma, mesonephric carcinoma, cervical carcinoma, small cell carcinomas, aggressive neuroblastoma, squamous cell carcinoma of the oral cavity, Wilms tumors, and alveolar rhabdomyosarcoma. PAX5 expression has also been detected in developing CNS and testis.
6 mL (RTU), 10 mL (RTU), 1 mL(Conc.), 0.5 mL (Conc.), 160 tests – Xmatrx Elite, 50 tests – Xmatrx Elite