DatasheetSDS

Pax5, or BSAP (B-cell lineage-specific activator protein), is a member of the paired box (Pax) family of transcription factors, it is an important transcription factor that is significant for B-cell differentiation and progression of B-cell development beyond the early pro-B (pre-B1) cell stage. Pax5 may play important role in spermatogenesis. The Pax proteins are key transcription factor regulating early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. Pax5 protein expression has also been detected in developing CNS and testis therefore, this indicated Pax5 proteins also play a significant role in neural development and spermatogenesis apart from there role in B-cell differentiation