p57 kip2 is a protein which is cyclin-dependent kinase inhibitor (CDKI) and is paternally imprinted that is being expressed from maternal allele. P57 is an imprinted gene located at the chromosomal locus 11p15.5. The cyclin-dependent kinase inhibitor which belongs to the CIP/KIP family also includes additionally p21CIP1/WAF1 and p27KIP1. It is one of the less studied CIP/KIP member and has an important role in embryogenesis. p57 kip2 regulates the cell cycle. Few functions have been attributed to this protein also includes cytoskeleton organization. p57 kip2 is frequently down-regulated in many common human malignancies by several mechanisms showing its anti-oncogenic function.
6 mL (RTU), 10 mL (RTU), 1 mL(Conc.), 0.5 mL (Conc.), 50 tests – Xmatrx Elite, 200 tests – Xmatrx Elite, 5 slides – Manual, 5 slides – Xmatrx