p57 kip2 is a protein which is cyclin-dependent kinase inhibitor (CDKI) and is paternally imprinted that is being expressed from maternal allele. P57 is an imprinted gene located at the chromosomal locus 11p15.5. The cyclindependent kinase inhibitor which belongs to the CIP/KIP family also includes additionally p21CIP1/WAF1 and p27KIP1. It is one of the less studied CIP/KIP member and has an important role in embryogenesis. p57 kip2 regulates the cell cycle. Few functions have been attributed to this protein also includes cytoskeleton organization. p57 kip2 is frequently downregulated in many common human malignancies by several mechanisms showing its anti-oncogenic function.
Intended Use: IVD
Antibody Type: Monoclonal
Clone: KP39
Source: Mouse
Tissue Type: Heart Tissue

Related products

View All