Tumor protein p53, a nuclear protein, plays an crucial role in cell cycle regulation, specifically in G0 to G1 checkpoint transition. Tumor protein p53 levels are very low in normal cells, it acts as a tumor suppressor by either promoting apoptosis or cell cycle arrest according to tissue physiology or cell cycel stage. p53 is overexpressed in over 50% of human cancers. Accumulation of mutant p53 detected by positive immunohistochemical staining has been reported in breast, lung, colon, stomach, bladder, and testis carcinomas, soft-tissue sarcomas, and melanomas.
|Tissue Type/Cancer Type|
0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 200 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual