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Anti-p53 Protein

SKU: AM195GP Categories: , , ,
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Product Description

Tumor protein p53, a nuclear protein, plays an crucial role in cell cycle regulation, specifically in G0 to G1 checkpoint transition. Tumor protein p53 levels are very low in normal cells, it acts as a tumor suppressor by either promoting apoptosis or cell cycle arrest according to tissue physiology or cell cycel stage. p53 is overexpressed in over 50% of human cancers. Accumulation of mutant p53 detected by positive immunohistochemical staining has been reported in breast, lung, colon, stomach, bladder, and testis carcinomas, soft-tissue sarcomas, and melanomas.

Intended Use

IVD

Antibody Type

Monoclonal

Clone

BP53-12-1

Source

Mouse

Tissue Type/Cancer Type

Breast Ca

Pack

0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 200 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual