p27kip1 (p27) is a cyclin kinase inhibitor belongs to the universal cyclin-dependent kinase inhibitor (CDKI) family. The phosphorylation on serine 10 (s10) and threonine 187 (T187) of p27/Kip1 regulates its activity. p27/Kip1 induces arrest at G1 check point and it inhibits cyclinE-Cdk2 complex, cyclinA-CDK2 and cyclinD1-CDK4 complexes. In normal cells the expression level of p27/Kip1 is high, but level of p27/Kip1 protein expression decreases in many types of cancers, and appears to be a poor prognostic factor in several tumor models, including carcinomas of the lung, breast, colorectal, and prostate
| Intended Use | IVD |
|---|---|
| Antibody Type | Monoclonal |
| Clone | DCS72 |
| Source | Mouse |
| Tissue Type/Cancer Type | Breast |
| Pack | 0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual |
