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Anti-p27 (Kip1)

SKU: AM396GP Categories: , , ,
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Product Description

p27kip1 (p27) is a cyclin kinase inhibitor belongs to the universal cyclin-dependent kinase inhibitor (CDKI) family. The phosphorylation on serine 10 (s10) and threonine 187 (T187) of p27/Kip1 regulates its activity. p27/Kip1 induces arrest at G1 check point and it inhibits cyclinE-Cdk2 complex, cyclinA-CDK2 and cyclinD1-CDK4 complexes. In normal cells the expression level of p27/Kip1 is high, but level of p27/Kip1 protein expression decreases in many types of cancers, and appears to be a poor prognostic factor in several tumor models, including carcinomas of the lung, breast, colorectal, and prostate

Intended Use

IVD

Antibody Type

Monoclonal

Clone

DCS72

Source

Mouse

Tissue Type/Cancer Type

Breast

Pack

0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 200 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual