Anti-p21/WAF1, Clone CIP1/4377R


The p21/WAF1 protein is a p53 regulated gene product has been shown to mediate cell cycle arrest. The growth arrest is due to several properties of this protein, namely cyclin dependent kinase inhibition, and maintenance of cell cycle arrest at G2 by blocking the interaction of Cdc25C with PCNA and inhibition of stress activated protein kinases. In breast cancer the p21/WAF1 expression is in general seen to be negative.

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