DatasheetSDS

p16/INK4A is a tumor-suppressor protein member of the Ink4 family of CDK inhibitors. The abnormalities arising in genes controlling the G1 checkpoint can lead to escape from senescence and tumor development. The p16/INK4 binds to CDK4/6 or ternary complex and prevents the formation of cyclin D-bound CDK4/6 complex and prevents phosporylation of Rb family members, resulting in E2F1 binding and G1 cell cycle arrest, followed by inhibition of cell cycle progression. The expression of p16 INK4A is commonly associated with cellular senescence, disruption of the p16 INK4A gene is frequently associated with tumor developemt. Similarly it has been observed that p16/INK4A locus is deleted in a wide spectrum of tumors including melanoma, pancreatic adenocarcinoma, glioblastoma, certain leukemias, non-small cell lung cancer, cervical cancer, and bladder carcinoma