p105 is a proliferation-associated nuclear antigen that plays an key role in RNA transport, RNA metabolism, cell-cycle regulation. p105 shows increased expression in proliferating cells, it does not stain during the early phases of the cell cycle. p105 levels increase dramatically during G2 and mitosis. Within a cell p105 distribution varies with cell stages, it is localized to interchromatin regions during interphase and early prophase and becomes cytoplasmic in subsequent mitotic phases. Antibody to p105 is directed against two polypeptides with molecular mass of 105 and 41 kD. Antibody to p105 may prove useful in studying chromatin structure and malignant transformations. Anti-p105 is the only immunological reagent known to preferentially stain interchromatin granules, a domain within the nuclear matrix responsible for RNA synthesis
| Intended Use | IVD |
|---|---|
| Antibody Type | Monoclonal |
| Clone | 2B3 |
| Source | Mouse |
| Tissue Type/Cancer Type | Tonsil |
| Pack | 0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual |
