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Anti-OCT-3/4 [C-10]
SKU: AMB84GP Categories: , ,

Oct-3/4 (octamer-binding transcription factor-3 & 4), a member of POU transcription factors, was identified as a DNA-binding protein that activates gene transcription via a cis-element containing an octamer motif. It is expressed in early embryonic cells and germ cells and is central to the gene regulatory network responsible for self-renewal, pluripotency, and lineage commitment in embryonic stem cells and induced pluripotent stem cells. Oct3/4 is not expressed in adult tissues. It is the most widely recognized marker of totipotent embryonic stem cells. OCT3/4antibody is a useful aid for classification of specific subtypes of germ cell tumors including seminoma, embryonal carcinoma and intratubular germ cell neoplasia of unclassified type (IGCNU).

Intended Use

IVD

Antibody Type

Monoclonal

Clone

C-10

Source

Mouse

Tissue Type/Cancer Type

Adrenal Gland

Pack

6 mL (RTU), 100 Tests – Automation – i6000, 1 mL(Conc.), 0.5 mL (Conc.), 160 tests – Xmatrx Elite, 50 tests – Xmatrx Elite, 5 slides – Xmatrx, 5 slides – Manual