Octamer transcription factor-2 (OCT-2) possesses a leucine zipper domain and belongs to the POU family of transcription factors. It specifically binds to the octamer motif (5-ATTTCAT-3), activates immunoglobulin gene expression and regulates transcription in a number of tissues. OCT-2 is important for the expression of B cell specific genes, such as CD20 and CRISP-3. OCT-2 is expressed in mature B cells, predominantly germinal center B cells. Low expression of OCT-2 has been found in immature B cells, T cells and myelomonocytic cells, as well as epithelial and neuronal cells. The OCT-2 antibody labels various B cell lymphomas with strong expression in germinal center-derived lymphomas. In a study on Hodgkin’s lymphoma (HL), OCT-2 positivity was observed in all lymphocyte predominance HLs but none of the 29 classic HLs.
| Intended Use | IVD |
|---|---|
| Antibody Type | Monoclonal |
| Clone | EP115 |
| Source | Rabbit |
| Tissue Type/Cancer Type | Tonsil |
| Pack | 0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual |
