Octamer transcription factor-2 (OCT-2) leucine zipper possessing transcription factor and it belongs to the POU family of transcription factors. OCT-2 is expressed in mature B cells, predominantly germinal center B cells. OCT-2 regulates key elements of gene expression during B cell development. ?OCT-2 transcription factor binds to the octamer motif (5- ATTTCAT-3), induces expression of immunoglobulin genes. OCT- 2 gene expressions in neuronal cells and epithelial cells have also been reported. The OCT-2 antibody labels various B cell lymphomas with strong expression in germinal center-derived lymphomas. Recent study on Hodgkin’s lymphoma (HL) reported that, OCT-2 positivity has been identified in 15 out of 15 lymphocyte predominance HLs, but none expression has been seen in the 29 classic HLs.
|Tissue Type/Cancer Type|
0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 200 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual