NUT (Nuclear protein in Testis) is a nuclear unstructured protein encoded by the NUTM1 (NUT Midline Carcinoma Family Member 1) gene on chromosome 15. It plays a role in the regulation of proliferation and shuttles between the nucleus and cytoplasm. In most of NUT midline carcinomas (NMC), there is a chromosomal translocation between NUT and BRD4/ BRD3 resulting in BRD4-NUT or BRD3-NUT fusions which contribute to carcinogenesis by blocking epithelial cell differentiation. NUT cancers can be carcinomas, sarcomas, lymphomas, and other types of tumors, and are primarily reported in kidney, bladder, lung, breast, and metastasis to lymph nodes.
| Intended Use | IVD |
|---|---|
| Antibody Type | Nucleus & Cytoplasm |
| Clone | SNUPN/7363R |
| Source | Rabbit |
| Tissue Type/Cancer Type | Testis, colon tissue |
| Pack | 1 mL – Manual – Concentrate, 0.5 mL – Manual – Concentrate, 6 mL – Manual – RTU, 10 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 50 tests – NanoVIP, 160 Tests – Automation – Xmatrx |
