Nucleophosmin, also known as nucleolar phosphoprotein B23 or numatrin, is a protein that in humans is encoded by the NPM1 gene. Nucleophosmin is a nucleolar phosphoprotein more abundant in tumor cells than in normal resting cells. An increase in nucleophosmin protein level accompanies stimulation of the growth of normal cells, e.g., mitogen activation of B lymphocytes. This protein is concentrated in the granular region of the nucleolus, where ribosome assembly occurs is likely involved in the assembly of ribosomal proteinsinto ribosomes. .
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