The NKX3.1 gene is located on chromosome 8p21.2, whose expression is predominantly localized to prostate epithelium. The NKX3.1 protein acts as a nuclear transcription factor that has a critical function in prostate development and tumor suppression, and is a negative regulator of epithelial cell growth in prostate tissue. Apart from prostate epithelium, NKX3.1 is found in testis, ureter, and pulmonary bronchial mucous glands. NKX3.1 is a highly sensitive and specific marker for prostate adenocarcinoma in line with other prostate markers like Prostate Specific Antigen (PSA) and Prostein (p501S), particularly useful in low differentiated tumors where PSA and/or Prostein may be weakly expressed or lost. This suggests that immunohistochemical staining of NKX3.1, along with other prostate-restricted markers, may be valuable for the definitive determination of prostatic origin in poorly differentiated metastatic carcinomas.
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6 mL (RTU), 100 Tests – Automation – i6000, 1 mL(Conc.), 0.5 mL (Conc.), 160 tests – Xmatrx Elite, 50 tests – Xmatrx Elite, 5 slides – Xmatrx, 5 slides – Manual