NGFR (Nerve Growth Factor Receptor), also termed p75 or CD271, is the low-affinity NGFR (LNGFR) which binds NGF and other neutrophils, including BDNF, NT3 and NT4/5 with similar low-affinity. It is expressed in neuronal cells in various tissues and tumors with neuronal origin. Recent studies suggested that NGFR is also expressed in melanocytes, myoepithelial cells, basal-like cells, perivascular cells and lymphoid dendritic cells. NGFR is expressed not only in sympathetic and sensory neurons, but also in various neural crest cells or tumor derivatives such as melanocytes, Melanomas, Neurobastomas, Pheochromocytomas, Neurofibromas and neurotizednevi(Type C Melanocytes).
| Intended Use | IVD |
|---|---|
| Clone | NGFR5+NTR/912 |
| Antibody Type | Monoclonal |
| Source | Mouse |
| Tissue Type/Cancer Type | Astrocytoma tissue |
| Pack | 6 mL (RTU), 100 Tests – Automation – i6000, 1 mL(Conc.), 0.5 mL (Conc.), 160 tests – Xmatrx Elite, 50 tests – Xmatrx Elite, 5 slides – Xmatrx, 5 slides – Manual |
