Neuronal Nuclei, also known as NeuN, Fox-3, RBFOX3, is a 350 amino acid neuron-specific protein present in most neuronal cells of CNS and PNS. It is involved in the regulation of mRNA splicing and plays a role in regulating neural cell differentiation and nervous system development. NeuN is expressed in brain, including in cerebral cortex, hippocampus, thalamus, caudate/putamen, cerebellum, as well as in the spinal cord although, some neurons fail to be recognized by NeuN at all ages such as INL retinal cells, Purkinje cells, Cajal-Retzius cells, sympathetic ganglion cells and inferior olivary and dentate nucleus neurons. Dysfunctional NeuN has been associated with various neurological disorders such as neurodevelopmental delay, autism spectrum disorder, Benign rolandic epilepsy (BRE), and cognitive impairments.
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