The NEU protein is member of the human epidermal growth factor receptor (EGFR) family. Members of this family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3), and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. NEU protein is a trans-membrane receptor tyrosine kinase that is frequently over expressed in a number of carcinomas. ErbB2 hetero or homo-dimerizes with ErbB1, 3, and 4, and can activate different pathways including the PI3K, PLCγ, and MAPK pathways, depending on the ErbB receptor involved. Overexpression of the HER2/Neu protein is seen in various cancers such as ductal breast cancer, pulmonary and gastric adenocarcinomas and may play a role in the development and metastasis of gliomas, ovarian, breast, lung, and gastric cancer.
6 mL (RTU), 10 mL (RTU), 1 mL(Conc.), 0.5 mL (Conc.), 200 tests – Xmatrx Elite, 50 tests – Xmatrx Elite, 5 slides – Xmatrx, 5 slides – Manual