It is required for brain and eye development. It also promotes the disassembly of phosphorylated vimentin intermediate filaments(IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Nestin is required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells. Nestin is a marker for neuroepithelial stem cells, glioma cells and tumor endothelial cells during rapid growth. Nestin is also expressed by dermatomal cells and by myoblasts during the earliest stages of myogenesis.
|Tissue Type/Cancer Type||
6 mL (RTU), 100 Tests – Automation – i6000, 1 mL(Conc.), 0.5 mL (Conc.), 160 tests – Xmatrx Elite, 50 tests – Xmatrx Elite, 5 slides – Xmatrx, 5 slides – Manual