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Smooth Muscle-Myosin Heavy Chain (SM-MHC) is a structural protein located in the cytoplasm which is a major component of the contractile apparatus of the smooth muscle cells, as well as a myoepithelium-associated protein. The antibody to smooth muscle myosin heavy chain stains myoepithelial cells which help in distinguish benign breast lesions and carcinoma in situ from invasive tumors. SM-MHC also stains intact myoepithelial cell (MEC) layers in bronchioloalveolar lesions which is very helpful in differentiating benign and malignant tumors.