Datasheet SDS

Myogenin is a muscle-specific transcription factor that is responsible for the normal development of muscle fibers. Myf4 is part of the Myogenic regulatory factors family with MyoD, Myf5, and MRF4. This family of proteins contains a conserved DNA binding domain that binds to the E box DNA motif allowing regulation of myogenesis. Myogenin (Myf4) has also been known to transform non-muscle cells to muscle cells. Mice with homozygous null Myogenin (Myf4) gene tend to die soon after birth with severely underdeveloped muscles, therefore highlighting the importance of Myogenin (Myf4) in musculoskeletal development. Myogenin being muscle-specific can be used to identify muscle cells, or probes can be used to identify muscle cell precursors.