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MyoD1, known as myogenic differentiation 1 or myoblast determination protein 1, plays a major role in regulating muscle differentiation in animals. MyoD1 (45kDa) is a part of the family of myogenic regulatory factors that also include Myf5, Myf6 and Myogenin. MyoD1 is a transcription factor that promotes genes that permit myoblast proliferation. Mice born carrying mutant versions of non-functional Myf5 and MyoD1 are unable to develop any skeletal muscle and die shortly after birth. This implies the importance of MyoD1 as a myogenic marker. MyoD1 is responsible for mesodermal cells to commit to a myogenic lineage and maintaining this state. They are also responsible for repairing muscles after damage from activity or trauma. MyoD1 arrests the cell cycle in terminally differentiated myoblasts by regulating Cyclin and Cyclin D1