MSH6 is a member of Mutator S (MutS) DNA mismatch repair protein family encoded by mutS homolog 6 gene. Mutations inDNA mismatch repair genes Inherited (germline) such as MLH1, MSH2, MSH3, and MSH6 results in is microsatellite instability, these mutations are the major reason for hereditary nonpolyposis colorectal cancer (HNPCC) syndrome. Microsatellite instability detection in a tumor sample increases the chances of identifying a germline mutation in a DNA mismatch repair gene. MSI analysis is usually performed prior to proceeding with full mutation analysis of mismatch repair genes. Immunohistochemical (IHC) analysis of suspected HNPCC tumor samples has come into favor as a means of screening tissues which may carry a mutation or a deletion in one of the mismatch repair (MMR) genes
Intended Use: IVD
Antibody Type: Monoclonal
Clone: 2D4B5
Source: Mouse
Tissue Type/Cancer Type: Colon Ca