DatasheetSDS

MSH2 is a protein is involved in the mismatch repair process after DNA replication. It contains a DNA binding domain and two interaction domains, one for MSH3 or MSH6 (forming the MutS alpha or MutS beta complexes respectively) and the other for MutL homologs. Mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC). Mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and shown to be associated with microsatellite instability. 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers display microsatellite instability, which may suggest that DNA mismatch repair is not restricted to HNPCC but is a common feature in tumor initiation or progression.