MiTF (microphthalmia-associated transcription factor) is a melanocytic nuclear protein with basic helix-loop-helix (bHLH), leucine-zipper domains. It can directly associate with DNA as a homodimer and plays a major role as a master regulator in melanocyte proliferation, osteoclastogenesis and RPE (Retinal Pigment Epithelium) differentiation. The expression of MiTF is seen in melanocytes, osteoclasts, mast cells and heart. It functions as a melanoma oncogene in humans and mutations in the associated gene causes Waardenburg Syndrome type II in humans.
6 mL (RTU), 10 mL (RTU), 1 mL(Conc.), 0.5 mL (Conc.), 50 tests – Xmatrx Elite, 160 tests – Xmatrx Elite, 5 slides – Manual, 5 slides – Xmatrx