MiTF (microphthalmia-associated transcription factor) is a melanocytic nuclear protein with basic helix-loop-helix (bHLH), leucine-zipper domains. It can directly associate with DNA as a homodimer and plays a major role as a master regulator in melanocyte proliferation, osteoclastogenesis and RPE (Retinal Pigment Epithelium) differentiation. The expression of MiTF is seen in melanocytes, osteoclasts, mast cells and heart. It functions as a melanoma oncogene in humans and mutations in the associated gene causes Waardenburg Syndrome type II in humans.
Intended Use: IVD
Antibody Type: Monoclonal
Clone: C5/D5
Source: Mouse
Tissue Type: Tonsil Tissue

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