Melanoma marker is a cocktail antibody that has three melanoma-specific proteins, which include MART1, Tyrosinase and gp100. This cocktail antibody labels melanomas and tumors showing melanocytic differentiation.Melanoma-associated antigen recognized by T cells-1 (MART-1) (also known as Melan-A) is a melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. It is a transmembrane protein which is hydrophobic in nature. Tyrosinase is a coppercontaining metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. This Antibody is a useful marker for melanocytes and melanomas.gp100, also designated ME20-M, ME20-S and PMEL 17, is classified as a melanocyte differentiation antigen and is expressed at low levels in normal cell lines and tissues, but is upregulated in melanocytes.
| Intended Use | IVD |
|---|---|
| Antibody Type | Monoclonal |
| Clone | A103+T311+HMB45 |
| Source | Mouse |
| Tissue Type/Cancer Type | Melanoma tissue |
| Pack | 6 mL (RTU), 100 Tests – Automation – i6000, 1 mL(Conc.), 0.5 mL (Conc.), 160 tests – Xmatrx Elite, 50 tests – Xmatrx Elite, 5 slides – Xmatrx, 5 slides – Manual |
