LEF1 (Lymphoid Enhancer-binding Factor 1) is a functionally diverse member of the high mobility group (HMG) DNA binding protein family of transcription factors TCF/LEF. It participates as a regulator in Wnt signaling pathways and is an important factor in lymphopoiesis. It binds to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. LEF1 is expressed normally in T and pro-B cells but not expressed in mature B cells. Anti-LEF1 antibody may be used as an aid for differentiation of chronic lymphocytic leukemia/small lymphocytic lymphoma from other small B cell lymphomas.
|Tissue Type/Cancer Type||
Hodgkins Lymphoma tissue
6 mL (RTU), 100 Tests – Automation – i6000, 1 mL(Conc.), 0.5 mL (Conc.), 160 tests – Xmatrx Elite, 50 tests – Xmatrx Elite, 5 slides – Xmatrx, 5 slides – Manual