Anti-LEF1, CloneEP310


LEF1 (Lymphoid Enhancer-binding Factor 1) is a functionally diverse member of the high mobility group (HMG) DNA binding protein family of transcription factors TCF/LEF. It participates as a regulator in Wnt signaling pathways and is an important factor in lymphopoiesis. It binds to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. LEF1 is expressed normally in T and pro-B cells but not expressed in mature B cells. Anti-LEF1 antibody may be used as an aid for differentiation of chronic lymphocytic leukemia/small lymphocytic lymphoma from other small B cell lymphomas.
Intended Use: IVD
Antibody Type: Monoclonal
Clone: EP310
Source: Rabbit
Tissue Type/Cancer Type: Hodgkins Lymphoma tissue