DatasheetSDS

Laminin and type IV collagen are the two principal components of the basement membrane. Because type IV collagen and laminin are proteins found exclusively in the basement membrane, the antibodies to these two proteins selectively and specifically recognize basement membrane components. Laminin consists of a 220 kD subunit, which is disulfide-linked into larger complexes or even into the structural scaffolding of the basement membrane itself. In surgical pathology, laminin can be used as a marker to demonstrate morphologic change of basement membrane, which is helpful for interpreting the invasion of malignant tumors. Laminin could also be used to study histogenesis and pathogenesis of certain unknown lesions such as extracellular and intracellular hyaline bodies occurring in various diseases