LAG-3 (Lymphocyte Activation Gene 3) or CD223 belongs to the Ig superfamily and has high homology to CD4. LAG-3 is an inhibitory T-cell surface molecule that has been found to directly modulate T-cell homeostasis. LAG3 is expressed on populations of activated T cells, such as Tregs and natural killer (NK) cells, and some monocyte-derived cell populations. LAG3 negatively regulates cellular proliferation, activation, and homeostasis of T cells, and has been reported to play a role in Treg suppressive function. LAG3 is often co-expressed with PD-1 on the surface of tumor infiltrating lymphocytes, where the two proteins act independently to synergistically promote tumoral immune escape.
Intended Use: IVD
Antibody Type: Polyclonal
Clone: Polyclonal
Source: Rabbit
Tissue Type/Cancer Type: Tonsil