LAG-3 (Lymphocyte Activation Gene 3) or CD223 belongs to the Ig superfamily and has high homology to CD4. LAG-3 is an inhibitory T-cell surface molecule that has been found to directly modulate T-cell homeostasis. LAG3 is expressed on populations of activated T cells, such as Tregs and natural killer (NK) cells, and some monocyte-derived cell populations. LAG3 negatively regulates cellular proliferation, activation, and homeostasis of T cells, and has been reported to play a role in Treg suppressive function. LAG3 is often co-expressed with PD-1 on the surface of tumor infiltrating lymphocytes, where the two proteins act independently to synergistically promote tumoral immune escape.
|Tissue Type/Cancer Type|
0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 200 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual