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Anti-J chain

SKU: AM374GP Categories: , , ,
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Product Description

J chain is a small, glycopeptide of 15 kD. It is structurally unrelated to heavy or light chains, but is synthesized by all plasma cells that secrete polymeric immunoglobulins. J chains are present in a large proportion of the immunoglobulin-positive cells in the germinal centers of the tonsils and lymph nodes. B cells secrete J chain at an early stage of differentiation with the expression persisting in those cells destined to produce IgA or IgM. J chain has been proposed to play a role in the mucosal transport of polymeric Igs by the polymeric Ig receptor. The studies show that a significant proportion of deposited mesangial immunoglobulin in IgA nephropathy is dimeric, or J chain positive. This monoclonal antibody stains J chain in cytoplasm of positve cells. B cells secrete J chain at an early stage of differentiation with the expression persisting in those cells destined to produce IgA or IgM

Intended Use

IVD

Antibody Type

Monoclonal

Clone

JC88

Source

Mouse

Tissue Type/Cancer Type

Tonsil, Lymph Node

Pack

0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 200 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual