J chain is a small, glycopeptide of 15 kD. It is structurally unrelated to heavy or light chains, but is synthesized by all plasma cells that secrete polymeric immunoglobulins. J chains are present in a large proportion of the immunoglobulin-positive cells in the germinal centers of the tonsils and lymph nodes. B cells secrete J chain at an early stage of differentiation with the expression persisting in those cells destined to produce IgA or IgM. J chain has been proposed to play a role in the mucosal transport of polymeric Igs by the polymeric Ig receptor. The studies show that a significant proportion of deposited mesangial immunoglobulin in IgA nephropathy is dimeric, or J chain positive. This monoclonal antibody stains J chain in cytoplasm of positve cells. B cells secrete J chain at an early stage of differentiation with the expression persisting in those cells destined to produce IgA or IgM.
| Intended Use | IVD |
|---|---|
| Antibody Type | Monoclonal |
| Clone | SP105 |
| Source | Rabbit |
| Tissue Type/Cancer Type | Tonsil |
| Pack | 0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual |
