Integrase interactor 1 (INI-1), also known as hSNF5, is an integral component of the hSWI/SNF (SWItch/Sucrose NonFermentable) chromatin remodeling complex, which facilitates DNAdependent cellular processes including transcription, replication, and repair. The INI-1 gene is often mutated or deleted in malignant rhabdoid tumor (MRT), a tumor which is potentially mimicked by medulloblastoma and supratentorial primitive neuroectodermal tumors (sPNETs). INI-1 has shown to be useful in distinguishing between the three conditions as the majority of medulloblastomas and sPNETs are labeled by Anti-INI-1, while a lack of nuclear labeling by the same antibody is characteristic of MRT.
| Intended Use | IVD |
|---|---|
| Antibody Type | Monoclonal |
| Clone | SMARCB1/3984 |
| Source | Mouse |
| Tissue Type | Kidney Tissue |
| Pack | 6 mL (RTU), 100 Tests – Automation – i6000, 1 mL(Conc.), 0.5 mL (Conc.), 50 tests – Xmatrx Elite, 160 tests – Xmatrx Elite, 5 slides – Manual, 5 slides – Xmatrx |
