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Anti-INI1/SNF5/SMARCB1

SKU: AMB97-5M_GP Categories: , , ,
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Product Description

Integrase interactor 1 (INI-1), also known as hSNF5, is an integral component of the hSWI/SNF (SWItch/Sucrose Non-Fermentable) chromatin remodeling complex, which facilitates DNAdependent cellular processes including transcription, replication, and repair. The INI-1 gene is often mutated or deleted in malignant rhabdoid tumor (MRT), a tumor which is potentially mimicked by medulloblastoma and supratentorial primitive neuroectodermal tumors (sPNETs). INI-1 has shown to be useful in distinguishing between the three conditions as the majority of medulloblastomas and sPNETs are labeled by Anti-INI-1, while a lack of nuclear labeling by the same antibody is characteristic of MRT.

Intended Use

IVD

Antibody Type

Monoclonal

Clone

SMARCB1/3984

Source

Mouse

Tissue Type

Kidney Tissue

Pack

6 mL (RTU), 10 mL (RTU), 1 mL(Conc.), 0.5 mL (Conc.), 50 tests – Xmatrx Elite, 200 tests – Xmatrx Elite, 5 slides – Manual, 5 slides – Xmatrx