DatasheetSDS

Integrase interactor 1 (INI-1), also known as hSNF5, is an integral component of the hSWI/SNF (SWItch/Sucrose NonFermentable) chromatin remodeling complex, which facilitates DNA dependent cellular processes including transcription, replication, and repair. The INI-1 gene is often mutated or deleted in malignant rhabdoid tumor (MRT), a tumor which is potentially mimicked by medulloblastoma and supratentorial primitive neuroectodermal tumors (sPNETs). The morphology of MRTs can present challenges in differential diagnosis. The overall survival of MRTs relative to its potential mimics [medulloblastoma, supratentorial primitive neuroectodermal tumors (sPNETs)] is quite low, and thus differentiation from these other tumors is desirable. INI-1 has shown to be useful in distinguishing between the three conditions as the majority of medulloblastomas and sPNETs are labeled by Anti-INI-1, while a lack of nuclear labeling by the same antibody is characteristic of MRT.