DatasheetSDS

Inhibins are protein hormones secreted by gonads and dimeric in nature, they negatively regulate pituitary FSH synthesis and secretion. Inhibins contains an alpha and beta subunit that are linked by disulfide linkages. Two forms of inhibin differ in their beta subunits, beta subunits posses two distinct forms A and B, while there is a single identical alpha subunit. Inhibin B is secreted by testicular Sertoli cells comprises of the Inhibin alpha subunit disulfide linked to the Inhibin beta subunit. Inhibin B is the primary circulating form of Inhibin in most adult male mammals. Studies showed that Inhibin is a critical negative regulator of gonadal stromal cell proliferation and was the first secreted protein identified to have tumor-suppressor activity. Inhibin alpha-subunit immunoreactivity has been detected in Sertoli cells, spermatocytes and in some Leydig cells