Datasheet SDS

Inhibins are dimeric gonadal protein hormones that negatively regulate pituitary FSH synthesis and secretion. Inhibin contains an alpha and beta subunit linked by disulfide bonds. Two forms of inhibin differ in their beta subunits (A or B), while their alpha subunits are identical. Inhibin B is comprised of the Inhibin alpha subunit disulfide linked to the Inhibin beta subunit. Inhibin B is produced by testicular Sertoli cells and is the primary circulating form of Inhibin in most adult male mammals. Initial studies indicated that Inhibin is a critical negative regulator of gonadal stromal cell proliferation and was the first secreted protein identified to have tumor-suppressor activity. Inhibin alpha-subunit immunoreactivity has been detected in Sertoli cells, spermatocytes and in some Leydig cells.