IL6ST, also designated as Glycoprotein 130 (gp 130) IL6-beta, IL6RB, or CD130, is a transmembrane glycoprotein that is the founding member of the class of all cytokine receptors. It is a signal transducer shared by many cytokines including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), oncostatin M (OSM) and leukemia inhibitory factor (LIF). This protein functions as a part of the cytokine receptor complex and plays a critical role in regulating myocyte apoptosis. The binding of IL6ST to its receptor IL-6R initiates signal transmission and mutations in this gene lead to tumorigenesis, which might be a result of dysfunctional intracellular compartment signalling.
| Intended Use | IVD |
|---|---|
| Antibody Type | Monoclonal |
| Clone | IL6ST/4101 |
| Source | Mouse |
| Tissue Type/Cancer Type | Lymph node |
| Pack | 1 mL – Manual – Concentrate, 0.5 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 50 tests – NanoVIP, 100 Tests – Automation – i6000, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual |
