IL6ST, also designated as Glycoprotein 130 (gp 130) IL6-beta, IL6RB, or CD130, is a transmembrane glycoprotein that is the founding member of the class of all cytokine receptors. It is a signal transducer shared by many cytokines including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), oncostatin M (OSM) and leukemia inhibitory factor (LIF). This protein functions as a part of the cytokine receptor complex and plays a critical role in regulating myocyte apoptosis. The binding of IL6ST to its receptor IL-6R initiates signal transmission and mutations in this gene lead to tumorigenesis, which might be a result of dysfunctional intracellular compartment signalling.
Intended Use: IVD
Antibody Type: Monoclonal
Clone: IL6ST/4101
Source: Mouse
Tissue Type/Cancer Type: Lymph node

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