Interleukin-5 (IL-5), also called as T cell-replacing factor (TRF) is a T-cell derived cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. It is a critical regulator for eosinopoiesis, eosinophil maturation and activation. IL-5 binds to its receptor which is a heterodimer and regulates the expression of genes required for cell proliferation, survival and maturation. JAK-STAT, Btk and Ras/Raf-ERK signalling pathways regulates the cellular functions of IL5. IL-5 is considered as a target for the treatment of eosinophilic diseases.
| Intended Use | IVD |
|---|---|
| Antibody Type | Monoclonal |
| Clone | IL5/4161 |
| Source | Mouse |
| Tissue Type/Cancer Type | Thymus, Tonsil, Adrenal gland, Stomach tissues |
| Pack | 1 mL – Manual – Concentrate, 0.5 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 50 tests – NanoVIP, 100 Tests – Automation – i6000, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual |
