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Anti-IgG4 [IGHG4/2042R]

SKU: ANB75-5M_GP Categories: , , ,
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Product Description

IgG4 (Immunoglobulin G4) is rare subclass and constitutes to only 3-4% of human IgG in serum. It is a dynamic antibody which has unique biological ability to undergo Fab-arm exchange and limit immune complex formation. IgG4 acts as a blocking antibody in allergy which helps in inhibiting mast cell degranulation, but plays a deleterious role in malignant melanoma, by impeding IgG1-mediated anti-tumor immunity. The over expression of IgG4 is seen in inflammatory pseudo-tumor (IPT) and under expressed in inflammatory myofibroblastic tumor (IMT). There are an increased number of IgG4+ plasma cells in pulmonary nodular lymphoid hyperplasia (PNLH).

Intended Use

IVD

Pack

6 mL (RTU), 10 mL (RTU), 1 mL(Conc.), 0.5 mL (Conc.), 200 tests – Xmatrx Elite, 50 tests – Xmatrx Elite, 5 slides – Xmatrx, 5 slides – Manual