Immunoglobulin D (IgD) is one of the Immunoglobins with monomeric structure consisting of δ heavy chains and either κ or λ light chains. It is the major antigen receptor isotype co-expressed with IgM and plays a biological role as a transmembrane receptor molecule on the surface of mature/naive B cells. IgD is detected in the surface/cytoplasm of neoplastic cells of common small B lymphoid cell such as mantle cell lymphoma, small lymphocytic lymphoma, follicular lymphoma and marginal zone lymphoma. It is useful in distinguishing B-cell lineage derived from Lymphomas, Leukemias, and Plasmacytomas.
|Tissue Type/Cancer Type||
Tonsil and Lymphoid tissues
1 mL – Manual – Concentrate, 0.5 mL – Manual – Concentrate, 6 mL – Manual – RTU, 10 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 50 tests – NanoVIP, 160 Tests – Automation – Xmatrx