IgA is the most abundantly produced and secreted immunoglobulin in mucosal secretions. It is the main immunoglobulin found in mucous secretions such as tears, saliva, sweat, colostrums and secretions in the genitourinary and gastrointestinal tract. Structurally, IgA exists in two forms depending on its location in the body. Monomeric IgA is usually found in the serum which compromises of two heavy and two light chains. The light chains are similar to the other immunoglobulins. The secretory IgA is prevalent in the polymeric form of IgA. The polymeric IgA usually exists as dimers but tetramers have also been observed. Polymeric IgA contains of IgA, a J chain and a heavily glycosylated secretory component that is attach while being secreted. IgA has numerous functions including eliminating antigens, inhibiting bacterial adhesion, inhibiting macromolecule adhesion, enhancing non-specific defense mechanisms and, etc.
|Tissue Type/Cancer Type||
6 mL (RTU), 100 Tests – Automation – i6000, 1 mL(Conc.), 0.5 mL (Conc.), 160 tests – Xmatrx Elite, 50 tests – Xmatrx Elite, 5 slides – Xmatrx, 5 slides – Manual