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Anti-IDO

SKU: AM916GP Categories: , , ,
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Product Description

IDO or INDO (Indoleamine-pyrrole2,3-dioxygenase) is a heme containing intracellular enzyme that in humans is encoded by the IDO1 gene(1). IDO is the first and rate-limiting enzyme of tryptophan catabolism through kynurenine pathway, thus causing depletion of tryptophan which can cause halted growth of microbes as well as T cells(2). It has been shown that IDO permits tumor cells to escape the immune system by depletion of L-Trp in the microenvironment of cells. A wide range of human cancers such as prostatic, colorectal, pancreatic, cervical, gastric, ovarian, head, and lung, over express human IDO, and inhibition of the IDO pathway is emerging as an important modality for the treatment of cancer (3,4).

Intended Use

ASR

Antibody Type

Monoclonal

Clone

4D2

Source

Mouse

Tissue Type/Cancer Type

Tonsil/Spleen

Pack

0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 200 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual