Anti-IDH1 R132H


IDH1 (Isocitrate Dehydrogenase 1), a cytosolic enzyme in the Krebs citric acid cycle, exhibits the R132H mutation often seen in astrocytomas and oligodendroglial tumors, correlating with improved patient outcomes. This mutation causes abnormal IDH1 activity and the production of oncometabolite 2-hydroxyglutarate, promoting glioma formation and progression. IDH1 R132H aids in diagnosing different glioma grades and serves as a prognostic marker for gliomas and secondary glioblastoma multiforme, contributing to refining the molecular classification of adult gliomas when combined with other markers.
Regulatory Claim: IVD for Both
Clone: MRQ-67
Isotype: IgG
Localisation: Cyt
Source: Rabbit
Control Tissue: Acute Myeloid leukemia tissue

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