Datasheet SDS

This antibody identifies a 45kDa protein, which is recognized as isocitrate dehydrogenase (IDH1). It belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 converts the compound isocitrate to 2-ketoglutarate in both cytoplasm and peroxisomes. This reaction also release a molecule called NADPH, which is required for other cellular processes.The NADPH produced from IDH1 is required in the breakdown of fats for energy, and it also safeguard cells from harmful molecules called reactive oxygen species. Recently, an inactivating mutation of IDH1 has been found to be involved in glioblastoma. IDH1 emerges to function as a tumor suppressor that, when inactivated, contributes to tumorigenesis in part through activation of the HIF-1 pathway.