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Anti- IDH1, Clone IDH1/1152

SKU: AMA22GP Categories: ,
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Product Description

This antibody identifies a 45kDa protein, which is recognized as isocitrate dehydrogenase (IDH1). It resides to the isocitrate and isopropylmalate dehydrogenases family. Isocitrate dehydrogenase 1 converts a compound called isocitrate to another compound called 2-ketoglutarate in both cytoplasm and peroxisomes. This reaction also release a molecule called NADPH, which is required for other cellular processes. The NADPH produced from isocitrate dehydrogenase 1 is required in the breakdown of fats for energy, and it also safeguard cells from harmful molecules called reactive oxygen species. Recently, an inactivating mutation of IDH1 has been involved in glioblastoma. IDH1 emerges to function as a tumor suppressor that, when inactivated, contributes to tumorigenesis in part through activation of the HIF-1 pathway

Pack

6 mL (RTU), 10 mL (RTU), 1 mL(Conc.), 0.5 mL (Conc.), 200 tests – Xmatrx Elite, 50 tests – Xmatrx Elite