Ki-67 antigen is a nuclear antigen specifically associated with cell proliferation. Ki-67 is expressed in all proliferating cells which are in the active phases of the cell cycle (late G1, S, G2, and mitosis) but absent in resting cells. It is strictly associated with cell proliferation. During interphase, the Ki-67 antigen can be exclusivelly detected within the cell nucleus, whereas in mitosis most of the protein is relocated to the surface of the chromosomes. Ki-67 labeling index has been show to be elevated in early stage and further increased in advanced stages of various types of cancer including breast cancer, colon cancer, prostate cancer and brain cancer.
|Tissue Type/Cancer Type|
Lymphoma, Lymph Node, Tonsil
0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 200 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual