Hypoxia-inducible factor 1-alpha is known as HIF-1-alpha a protein that in humans is encoded by the HIF1A gene. HIF-1shows to activate hypoxia-responsive genes that are involved in multiple aspects of tumorigenesis and cancer progressionwhich also includes proliferation, metabolism, angiogenesis, invasion, metastasis and therapy resistance. It also plays animportant role in cellular and systemic responses to hypoxia. Hypoxia has been clinically demonstrated to predict an adverse treatment outcome in radio therapeutic management of cancer of the head and neck, uterine cervix and soft tissue sarcomas. HIF-1 alpha antibody may be used in analyzing the cancer cell response to therapy.
|Tissue Type/Cancer Type||
Breast Carcinoma tissue
6 mL (RTU), 100 Tests – Automation – i6000, 1 mL(Conc.), 0.5 mL (Conc.), 160 tests – Xmatrx Elite, 50 tests – Xmatrx Elite, 5 slides – Xmatrx, 5 slides – Manual