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Anti-Histone H3 [PHH3/471R]

SKU: ANB88-5M_GP Categories: , , ,
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Product Description

Histone H3 (also known as Histone H3.1t, H3/t, H3t, or H3/g) encoded by the gene HIST3H3/H3Ft, is one of the nuclear proteins responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. They play a crucial role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Acetylation and or methylation of Histone H3 occur in response to various stimuli and have a direct effect on the accessibility of chromatin to transcription factors and, therefore, gene expression. Hence, Histone H3 has been linked to various types of cancer as a biomarker through the aberrant expression of histone deacetylase (HDAC) enzymes and changes to chromatins.

Intended Use

IVD

Antibody Type

Monoclonal

Clone

PHH3/471R

Source

Rabbit

Tissue Type

Tonsil Tissue

Pack

6 mL (RTU), 10 mL (RTU), 1 mL(Conc.), 0.5 mL (Conc.), 50 tests – Xmatrx Elite, 200 tests – Xmatrx Elite, 5 slides – Manual, 5 slides – Xmatrx