Granzyme B is a single chain and single domain serine protease. Its structure is folded into two six-stranded Beta-barrels, which are connected by three trans domain segments. Granzyme B is one of the most common serine proteases present in the granules of Natural killer cells and cytotoxic T lymphocytes. Granzyme B is stored in secretory granules and secreted along with many other proteins such as perforin to induce apoptosis of harmful target cells such as allogeneic, virally infected and tumor cells. After being transported to the target cells, Granzyme B causes multiple cascades of activation and inactivation that ultimately leads to the apoptotic demise of the target cell. There is also some evidence that Granzyme B plays a role in moderating the immune response asides its apoptotic effects. Elevated levels of Granzyme B have been noticed in certain autoimmune diseases, further implicating its role in moderating the immune response. Granzyme B has potential to be effective in anti-cancer medicine, as Granzyme B and tumor fusion targeted therapeutics have shown promise in various models.
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6 mL (RTU), 100 Tests – Automation – i6000, 1 mL(Conc.), 0.5 mL (Conc.), 160 tests – Xmatrx Elite, 50 tests – Xmatrx Elite, 5 slides – Xmatrx, 5 slides – Manual